Single mutations in one gene rarely cause such different diseases . . .

New research gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget’s Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS).

https://www.sciencedaily.com/releases/2013/03/130313214009.htm