VCP Research Library
A VCP literature review and research information curated by our scientific team.
Valosin Containing Protein / p97
Also known as TERA; CDC48; FTDALS6
VCP/p97 is a member of the AAA ATPase family of proteins. It has multiple functions in protein degradation and clearance, autophagy, ERAD, mitochondrial and lysosomal function, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of several pathways NF-kappa B, PI3K/AKT, Wnt/PCP, JAK2.
The VCP protein forms a homohexameric complex that interacts with more than 40 cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes and also acts through non-ubiquitinated pathways. The complex is also found in the form of dodecamers.
Pathogenic variants in the VCP gene cause multisystem proteinopathy (MSP-1), formally reported as IBMPFD (inclusion body myopathy with Paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis), Charcot-Marie-Tooth disease, and Parkinsonism in human patients.
VCP STRUCTURE AND FUNCTIONS
Below are select publications concerning basic knowledge of VCP structure and functions.
MODULATION OF p97/VCP
Below are select publications and information on the modulation on VCP.
VCP IN OTHER DISEASES
VCP/p97 is a member of the AAA ATPase family of proteins.
DRUG DISCOVERY INTELLIGENCE / PATENTS
Current trial and drug discovery status on VCP