New Study identifies VCP as a central mediator.
Published in January 2019, the authors state, "Differentiated tissue is particularly vulnerable to alterations in protein and organelle homeostasis. ... To understand the relevance of VCP in differentiated tissue, we inactivated it in skeletal muscle of adult mice. Surprisingly, knockout muscle demonstrated a necrotic myopathy with increased macroautophagic/autophagic proteins and damaged lysosomes. ... Our data identifies VCP as central mediator of both lysosomal clearance and biogenesis in skeletal muscle. "